LNPs and SLNs脂质纳米颗粒(LNPs)和固体脂质纳米颗粒(SLNs)制备

Our High Pressure, high shear Homogenizers offer a scalable platform for Lipid Nanoparticles formulation during which our technology achieves consistent particle sizes with narrow distributions.

Lipid Nanoparticles (LNPs) and Solid Lipid Nanoparticles (SLNs) have an average diameter between 10 and 1000 nanometers and are one of the most clinically advanced non-viral gene delivery systems. They can effectively deliver nucleic acids, overcoming a barrier preventing the development and application of genetic medicines.

Lipid Nanoparticles - our High Pressure Homogenizers

Easy to scale systems from Lab R&D to full production units that can produce a very high number of doses.

High shear processing efficiently creating consistent particle sizes with narrow distributions, increasing product stability and improving processes such as sterilization.

Industry-leading pressures up to 60,000 psi (4200 bar, 420 MPa).

Sophisticated temperature control both pre-processing and post homogenization.

CIP and SIP capability. Full documentation packs, provision of DQ/IQ/OQ.

Easy to use, sterlize and maintain with low ongoing ownership costs.

Pilot - Production Homogenizing System

Lipid Nanoparticles Production Homogenizer

Lab scale Homogenizer

Lipid Nanoparticles Lab Homogenizer

Solid Lipid Nanoparticle 

Wikipedia. Solid lipid nanoparticles (SLNs). There is only one phospholipid layer because the bulk of the interior of the particle is composed of lipophilic substance. Payloads such as modRNA, RNA vaccine or others can be embedded in the interior, as desired. Optionally, targeting-molecules such as antibodies, cell-targeting peptides, and/or other drug molecules can be bound to the exterior surface of the SLN.

我们的高压、高剪切均质机为脂质纳米颗粒配方提供了可扩展的平台，在此过程中，我们的技术实现了一致的颗粒大小和狭窄的分布。

脂质纳米颗粒(LNPs)和固体脂质纳米颗粒(SLNs)的平均直径在10到1000纳米之间，是临床最先进的非病毒基因传递系统之一。它们可以有效地传递核酸，克服了阻碍基因药物开发和应用的障碍。

脂质纳米颗粒-我们的高压微射流均质器

易于将系统从实验室研发扩展到可以生产非常高剂量的全生产单位。

高剪切加工有效地创造了一致的颗粒尺寸与狭窄的分布，增加了产品的稳定性和改进工艺，如杀菌。

压力高达60000 psi (4200 bar, 420 MPa)，处于行业领先水平。

复杂的温度控制，包括预处理和后均质。

CIP和SIP能力。完整的文件包，提供DQ/IQ/OQ。

易于使用，消毒和维护与低持续拥有成本。

中试生产均质系统

脂质纳米颗粒生产均质机

实验室规模高压均质器

脂质纳米颗粒实验室均质器

固体脂质纳米粒

维基百科。固体脂质纳米颗粒(SLNs)。由于颗粒内部的大部分是由亲脂性物质组成的，所以只有一个磷脂层。有效载荷，如modRNA, RNA疫苗或其他可以嵌入内部，根据需要。选择性地，靶向分子，如抗体，细胞靶向肽，和/或其他药物分子可以结合到SLN的外表面。